For an oocyte to be ready for fertilization and progress into an embryo, the ideal list of genes has to be turned on. Namekawa suspected this pre-programming of your oocyte genome takes place in a number of levels — the initial just one setting up within the time a woman is born. He believed that chromatin remodeling proteins did much of the perform, by shifting spools all around.

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Namekawa thinks that in human oocytes, alterations in these designs could disrupt the fragile choreography of genes currently being turned on and off at the appropriate times — leaving them unprepared for fertilization or progress into nutritious embryos. Improvements in chromatin structure as an oocyte ages might also impression just how that chromosomes segregate during mobile division.

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